Journal of the American Nutrition Association · 2024
Negative Association of Serum β-Cryptoxanthin With Benzene and Its Derivatives.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lu Yu-Yang, Chen Hao-En, Chen Wei-Liang
Аннотация
OBJECTIVE: Benzene is widely recognized as a potential carcinogen. Furthermore, the deficiency of specific nutrients may render individuals more vulnerable to cancer. For instance, β-cryptoxanthin, which possesses anti-inflammatory, antioxidant, and anticancer properties, has been identified as one such nutrient. Elevated benzene levels and reduced β-cryptoxanthin levels are reportedly correlated with an augmented susceptibility to cancer. To date, whether these 2 substances are linked with one another in the above correlation is yet to be determined.
METHOD: This study included 1358 participants with data on the serum concentration of β-cryptoxanthin as well as benzene and its derivatives. The data were sourced from the 2003-2004 National Health and Nutrition Examination Survey, a cross-sectional survey of the noninstitutionalized US population. Headspace solid-phase microextraction with gas chromatography and mass spectrometry was used to measure serum benzene and its derivatives, while high-performance liquid chromatography using multiwavelength photodiode-array absorbance detection was employed to quantify serum β-cryptoxanthin.
RESULTS: In this study, male and female participants showed average β-cryptoxanthin levels of 9.10 ± 6.35 and 9.92 ± 8.95 ug/dL, respectively (p = 0.049). Styrene exhibited the strongest correlation with the change in β-cryptoxanthin concentration (β = -3.30, p for trend <0.001) upon comparing highest-quartile participants with those in the lowest quartile, followed by benzene (β = -2.95, p for trend <0.001), toluene (β = -2.90, p for trend <0.001), and ethylbenzene (β = -1.43, p for trend = 0.09). Subgroup analysis by sex displayed a statistically significant negative correlation of β-cryptoxanthin with benzene, styrene, and toluene in both the unadjusted and multivariate-adjusted models.
CONCLUSIONS: The sera of noninstitutionalized US individuals exhibit a negative association of β-cryptoxanthin levels with benzene and its derivatives. Styrene demonstrates the strongest link with a substantial decline in serum β-cryptoxanthin levels, followed by benzene, toluene, and ethylbenzene.
METHOD: This study included 1358 participants with data on the serum concentration of β-cryptoxanthin as well as benzene and its derivatives. The data were sourced from the 2003-2004 National Health and Nutrition Examination Survey, a cross-sectional survey of the noninstitutionalized US population. Headspace solid-phase microextraction with gas chromatography and mass spectrometry was used to measure serum benzene and its derivatives, while high-performance liquid chromatography using multiwavelength photodiode-array absorbance detection was employed to quantify serum β-cryptoxanthin.
RESULTS: In this study, male and female participants showed average β-cryptoxanthin levels of 9.10 ± 6.35 and 9.92 ± 8.95 ug/dL, respectively (p = 0.049). Styrene exhibited the strongest correlation with the change in β-cryptoxanthin concentration (β = -3.30, p for trend <0.001) upon comparing highest-quartile participants with those in the lowest quartile, followed by benzene (β = -2.95, p for trend <0.001), toluene (β = -2.90, p for trend <0.001), and ethylbenzene (β = -1.43, p for trend = 0.09). Subgroup analysis by sex displayed a statistically significant negative correlation of β-cryptoxanthin with benzene, styrene, and toluene in both the unadjusted and multivariate-adjusted models.
CONCLUSIONS: The sera of noninstitutionalized US individuals exhibit a negative association of β-cryptoxanthin levels with benzene and its derivatives. Styrene demonstrates the strongest link with a substantial decline in serum β-cryptoxanthin levels, followed by benzene, toluene, and ethylbenzene.