[Prevention of prion disease transmission].

Prion infections lead to fatal diseases of the CNS, including Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy(BSE) in cows. Iatrogenic CJD which have been transmitted through dura-matter transplantation, administration of pituitary tissue extracts, corneal transplantation, or neurosurgical procedures. There are not thought to be infectious agents in blood of sporadic CJD patients. However three recipients of blood donated by individuals who subsequently developed variant CJD in United Kingdam. We introduce the guideline for CJD infection through medical procedure made in 2003 and arouse attention to risk of blood in variant CJD patients.