[Morphometric parameters of hepatic lobule vessels in mice during the restorative period after leg injury].

The diameters of the hepatic lobule vessels (interlobular veins, central veins, interlobular arteries, intralobular sinusoidal capillaries, interlobular bile ducts) were been studied 3, 7 and 28 days after shin bones fracture in CBA mice (n=30). Most pronounced changes of morphometric parameters indicative of hemodynamic disturbances, were found 3 days after the trauma. The increase of the diameter of central, interlobulat veins and sinusoidal capillaries took place, together with the decrease of the diameter of interlobular arteries, which, probably, promoted the reduction of arterial blood supply. The tendency for normalization of the diameter of interlobular veins, arteries and bile ducts was detected 28 days after the start of an experiment. However, the diameter of the central veins and sinusoidal capillaries remained significantly higher than in control group. Thus, it was found that the leg bone fracture was accompanied by the changes of morphometric parameters of the hepatic lobule, mediated by the organ response to injury.