[Effect of Panax notoginseng saponin on Ca2+, CaM in craniocerebral injury].

OBJECTIVE

To explore the change of nerve cell Ca(2+)-overload, Ca(2+)-CaM and the effect of Panax Notoginseng saponin (PNS) on it in craniocerebral injury.

METHODS

Blood and brain contents of Ca2+, CaM were examined by radio-immunoassay (RIA) and atomic absorption spectrometry(AAS), and effect of PNS on these parameters was observed in craniocerebral injury rabbits.

RESULTS

The levels of Ca2+ and CaM in blood and those in brain were significantly positively correlated. PNS could reduce Ca2+ and CaM contents in blood and in cerebral tissue.

CONCLUSION

PNS could block the Ca(2+)-overload and Ca(2+)-CaM complex production in nerve cell after cranial cerebral injury, thereby to protect the injured brain in a certain degree. Blood CaM level is an objective index for assessment of Ca(2+)-overload in nerve cell.