Obstetrics and gynecology · 2010
Gestational diabetes leading to diagnosis and management of multiple endocrine neoplasia type 2a.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Sherer David M, Dalloul Mudar, Salame Ghadir, Kalidas Puja, Zinn Harry L, Abulafia Ovadia
Аннотация
BACKGROUND: Multiple endocrine neoplasia (MEN) type 2a is an autosomal dominant syndrome caused by specific proto-oncogene mutations characterized by medullary carcinoma of the thyroid, pheochromocytoma, and, occasionally, multiglandular parathyroid hyperplasia, which rarely complicates pregnancy. Secondary diabetes rarely has been reported in association with principal endocrinopathies complicating pregnancy.
CASE: A 34-year-old primiparous woman with recently diagnosed gestational diabetes had repeated episodes of dizziness at 30 weeks of gestation, initially attributed to glyburide. Continued episodes of dizziness and later-appearing bouts of severe headache, palpitations, diaphoresis, severe hypertension, and marked tachycardia led to diagnosis and management of MEN type 2a complicating pregnancy.
CONCLUSION: Patients with MEN type 2a complicating pregnancy may present with gestational diabetes.
CASE: A 34-year-old primiparous woman with recently diagnosed gestational diabetes had repeated episodes of dizziness at 30 weeks of gestation, initially attributed to glyburide. Continued episodes of dizziness and later-appearing bouts of severe headache, palpitations, diaphoresis, severe hypertension, and marked tachycardia led to diagnosis and management of MEN type 2a complicating pregnancy.
CONCLUSION: Patients with MEN type 2a complicating pregnancy may present with gestational diabetes.