Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia.

BACKGROUND

Spinal cord injury has been reported after perinatal asphyxia in full-term neonates.

OBJECTIVES

To examine the role of excessive nitric oxide production in perinatal spinal cord injury.

SUBJECTS AND

METHODS

Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT).

RESULTS

NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants.

CONCLUSIONS

excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.