American journal of obstetrics and gynecology · 2010
Respiratory compliance in preterm infants after a single rescue course of antenatal steroids: a randomized controlled trial.
СтатьяРандомизированное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ошибки и ограничения
История · было → стало
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McEvoy Cindy, Schilling Diane, Peters Dawn, Tillotson Carrie, Spitale Patricia, Wallen Linda, Segel Sally, Bowling Susan, Gravett Michael, Durand Manuel
Аннотация
OBJECTIVE: To compare respiratory compliance and functional residual capacity in infants randomized to a rescue course of antenatal steroids vs placebo.
STUDY DESIGN: Randomized, double-blinded trial. Pregnant women > or =14 days after initial antenatal steroids were randomized to rescue antenatal steroids or placebo. The primary outcomes were measurements of respiratory compliance and functional residual capacity. This study is registered with clinicaltrials.gov (NCT00669383).
RESULTS: Forty-four mothers (56 infants) received rescue antenatal steroids and 41 mothers (57 infants) received placebo. There was no significant difference in birthweight, or head circumference. Infants in the rescue group had an increased respiratory compliance (1.21 vs 1.01 mL/cm H(2)O/kg; adjusted 95% confidence interval, 0.01-0.49; P = .0433) compared with placebo. 13% in the rescue vs 29% in the placebo group required > or =30% oxygen (P < .05). Patients delivered at < or =34 weeks had greater pulmonary benefits.
CONCLUSION: Infants randomized to rescue antenatal steroids have a significantly increased respiratory compliance compared with placebo.
STUDY DESIGN: Randomized, double-blinded trial. Pregnant women > or =14 days after initial antenatal steroids were randomized to rescue antenatal steroids or placebo. The primary outcomes were measurements of respiratory compliance and functional residual capacity. This study is registered with clinicaltrials.gov (NCT00669383).
RESULTS: Forty-four mothers (56 infants) received rescue antenatal steroids and 41 mothers (57 infants) received placebo. There was no significant difference in birthweight, or head circumference. Infants in the rescue group had an increased respiratory compliance (1.21 vs 1.01 mL/cm H(2)O/kg; adjusted 95% confidence interval, 0.01-0.49; P = .0433) compared with placebo. 13% in the rescue vs 29% in the placebo group required > or =30% oxygen (P < .05). Patients delivered at < or =34 weeks had greater pulmonary benefits.
CONCLUSION: Infants randomized to rescue antenatal steroids have a significantly increased respiratory compliance compared with placebo.
Предметные рубрики MeSH
BetamethasoneDouble-Blind MethodFemaleFunctional Residual CapacityGestational AgeGlucocorticoidsHumansInfant, NewbornInfant, PrematureIntention to Treat AnalysisMalePatient SelectionPregnancyProspective StudiesRespiratory Distress Syndrome, NewbornRespiratory MechanicsStatistics, NonparametricTreatment Outcome