Future oncology (London, England) · 2015
Schwannomas exhibit distinct size-dependent gene-expression patterns.
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Mehrian-Shai Ruty, Freedman Shany, Shams Soheil, Doherty Joni, Slattery William, Hsu Nancy Ya-Hsuan, Reichardt Juergen K V, Andalibi Ali, Toren Amos
Аннотация
AIM: Neurofibromatosis type 2 (NF2)-associated vestibular schwannomas have variable size at presentation which presents a unique challenge in NF2 patient management. Therefore, we investigated the molecular signature characteristic of the differences in size for improved individualized precise therapy.
MATERIALS & METHODS: RNA expression analysis was performed on 15 small and 27 large NF2-associated vestibular schwannoma tumors using a microarray analyzing over 47,000 transcripts.
RESULTS: A signature of 11 genes was found to be correlated with NF2 tumor size.
CONCLUSION: We have identified the genetic hallmark that differentiates large NF2-associated tumors from smaller tumors. This is the first time that these genes have been shown to be the hallmark for NF2 tumor size.
MATERIALS & METHODS: RNA expression analysis was performed on 15 small and 27 large NF2-associated vestibular schwannoma tumors using a microarray analyzing over 47,000 transcripts.
RESULTS: A signature of 11 genes was found to be correlated with NF2 tumor size.
CONCLUSION: We have identified the genetic hallmark that differentiates large NF2-associated tumors from smaller tumors. This is the first time that these genes have been shown to be the hallmark for NF2 tumor size.