Automatic segmentation of cone beam CT images using treatment planning CT images in patients with prostate cancer.

Cone-beam computed tomography-based online adaptive radiotherapy (CBCT-based online ART) is currently used in clinical practice; however, deep learning-based segmentation of CBCT images remains challenging. Previous studies generated CBCT datasets for segmentation by adding contours outside clinical practice or synthesizing tissue contrast-enhanced diagnostic images paired with CBCT images. This study aimed to improve CBCT segmentation by matching the treatment planning CT (tpCT) image quality to CBCT images without altering the tpCT image or its contours. A deep-learning-based CBCT segmentation model was trained for the male pelvis using only the tpCT dataset. To bridge the quality gap between tpCT and routine CBCT images, an artificial pseudo-CBCT dataset was generated using Gaussian noise and Fourier domain adaptation (FDA) for 80 tpCT datasets (the hybrid FDA method). A five-fold cross-validation approach was used for model training. For comparison, atlas-based segmentation was performed with a registered tpCT dataset. The Dice similarity coefficient (DSC) assessed contour quality between the model-predicted and reference manual contours. The average DSC values for the clinical target volume, bladder, and rectum using the hybrid FDA method were 0.71 ± 0.08, 0.84 ± 0.08, and 0.78 ± 0.06, respectively. Conversely, the values for the model using plain tpCT were 0.40 ± 0.12, 0.17 ± 0.21, and 0.18 ± 0.14, and for the atlas-based model were 0.66 ± 0.13, 0.59 ± 0.16, and 0.66 ± 0.11, respectively. The segmentation model using the hybrid FDA method demonstrated significantly higher accuracy than models trained on plain tpCT datasets and those using atlas-based segmentation.