TNF-α-Induced Paneth Cell Dysfunction and Gut Bacterial Translocation: Implications for the Mechanism of Enterogenic Infection in Sepsis.

In a recent Cell Host & Microbe paper, Wallaeys et al. demonstrate that TNF signaling critically regulates Paneth cell dysfunction and bacterial sepsis pathogenesis, and highlights a critical localized mechanism in the gut, making a substantial contribution to our understanding of TNF's role in gut-derived sepsis pathogenesis.