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DOI 10.1159/000530373

Медицинская библиотека · Case reports in gastroenterology · 2023

Gastrointestinal Eosinophilic Granulomatosis with Polyangiitis following a Clostridium difficile Infection.

Thompson Michelle G, Boyle Julia T, Muench Alexandria, Lampe Elizabeth W, Chung Debbie, Grandner Michael A, Jemmott Iii John B, Seixas Azizi A, Jean-Louis Girardin, Perlis Michael L

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Аннотация

BACKGROUND

Few studies have assessed sleep across all sleep continuity variables (eg, sleep latency [SL], number of awakenings [NWAK], wake after sleep onset [WASO], early morning awakenings [EMA], total sleep time [TST], total wake time [TWT]) concurrently, at the community level, leading to gaps in understanding racial sleep disparities. Moreover, many studies do not examine sleep-related problem endorsement and daytime function.

PURPOSE: To examine race differences in insomnia symptom severity (eg, sleep continuity disturbance [SCD]), problem endorsement, and daytime dysfunction among Black and White non-Hispanic adults.

PARTICIPANTS AND

METHODS

Participants (N=8172) living in Greater Philadelphia completed an online community survey about their sleep between 2011 and 2021. Chi-square and t-test analyses were used to compare sleep-related differences by race. Multiple regression analyses were conducted to investigate the effect of race on sleep, controlling for age, sex, BMI, and education.

RESULTS

Black non-Hispanics had significantly worse SL (Δ>3 min), WASO (Δ>8.4 min), and TWT (Δ >12.1 min) but not NWAK (Δ<0.4). Black non-Hispanics also reported substantially lower TST (Δ>36.8 min). Appreciable effect sizes ranged from .01 to .44. White non-Hispanics consistently endorsed greater daytime dysfunction with small effects ranging from .07 to .14.

CONCLUSION

Findings suggest that Black non-Hispanics experience less restorative sleep, which can lead to impaired cognitive function, mood disturbances, and increased risk of chronic illness. Observed differences in TST may be due to the unmeasured effects of EMA or to reduced time in bed, underscoring the importance of comprehensive approaches to understanding sleep disturbances like insomnia. Addressing insomnia severity using multidimensional approaches and with targeted interventions, such as Cognitive Behavioral Therapy for Insomnia and/or systematic sleep extension, could help improve sleep health. Moreover, examining differences in sleep across sociodemographic characteristics leads to nuanced understandings that highlight the importance of developing targeted, precision-based behavioral health interventions.

Для цитирования: Thompson Michelle G, Boyle Julia T, Muench Alexandria, Lampe Elizabeth W, Chung Debbie, Grandner Michael A, Jemmott Iii John B, Seixas Azizi A, Jean-Louis Girardin, Perlis Michael L. Gastrointestinal Eosinophilic Granulomatosis with Polyangiitis following a Clostridium difficile Infection.. Case reports in gastroenterology. 2023. DOI: 10.1159/000530373.
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