Annals of neurology · 2002
Creutzfeldt-Jakob disease cluster in an Australian rural city.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Collins Steven, Boyd Alison, Fletcher Ashley, Kaldor John, Hill Andrew, Farish Stephen, McLean Catriona, Ansari Zahid, Smith Margaret, Masters Colin L
Аннотация
Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.