Genetic syndromes associated with skin cancer.

Most skin cancers are amenable to cure with early diagnosis and appropriate treatment; however, skin cancers associated with genetic syndromes may give rise to some of the most relentless, deforming, and ultimately lethal skin cancers clinicians will ever encounter. This article reviews the commonly accepted genetic syndromes associated with skin cancer, details their clinical pictures and key points of recognition and diagnosis, considers associated relevant clinical concerns, and discusses therapeutic options and dangers.