Current molecular pharmacology · 2018
CRH Receptors in Human Reproduction.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Makrigiannakis Antonis, Vrekoussis Thomas, Zoumakis Emmanuel, Navrozoglou Iordanis, Kalantaridou Sophia N
Аннотация
BACKGROUND: Corticotropin releasing hormone (CRH), the main peptide-mediator of stress, has been found in the female reproductive system.
OBJECTIVE: Herein, the role of CRH receptors in the female reproductive system is presented.
RESULTS: It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition.
CONCLUSION: Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery.
OBJECTIVE: Herein, the role of CRH receptors in the female reproductive system is presented.
RESULTS: It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition.
CONCLUSION: Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery.