CRH Receptors in Human Reproduction.

BACKGROUND

Corticotropin releasing hormone (CRH), the main peptide-mediator of stress, has been found in the female reproductive system.

OBJECTIVE

Herein, the role of CRH receptors in the female reproductive system is presented.

RESULTS

It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition.

CONCLUSION

Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery.