Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Wang Dingyi, Fan Guohui, Wu Sinan, Yang Ting, Xu Jianying, Yang Lan, Zhao Jianping, Zhang Xiangyan, Bai Chunxue, Kang Jian, Ran Pixin, Shen Huahao, Wen Fuqiang, Huang Kewu, Chen Yahong, Sun Tieying, Shan Guangliang, Lin Yingxiang, Xu Guodong, Wang Ruiying, Shi Zhihong, Xu Yongjian, Ye Xianwei, Song Yuanlin, Wang Qiuyue, Zhou Yumin, Li Wen, Ding Liren, Wan Chun, Yao Wanzhen, Guo Yanfei, Xiao Fei, Lu Yong, Peng Xiaoxia, Zhang Biao, Xiao Dan, Wang Zuomin, Bu Xiaoning, Zhang Hong, Zhang Xiaolei, An Li, Zhang Shu, Zhu Jianguo, Cao Zhixin, Zhan Qingyuan, Yang Yuanhua, Liang Lirong, Dai Huaping, Cao Bin, He Jiang, Wang Chen, China Pulmonary Health (CPH) Study Group
Аннотация
METHODS: Based on a nationwide epidemiological study of pulmonary health among adults in mainland China (China Pulmonary Health, CPH study) between 2012 and 2015, participants ≥40 years who completed the questionnaire and spirometry tests were recruited and randomly divided into development set and validation set by the ratio of 2:1. Parameters including sex, age, BMI, residence, education, smoking status, smoking pack-years, biomass exposure, parental history of respiratory diseases and daily respiratory symptoms were initially selected for the development of scoring system. Receiver operating characteristic (ROC) curve, area under curve (AUC), positive and negative predictive values were calculated in development set and validation set.
RESULTS: After random split by 2:1 ratio, 22443 individuals were assigned to development set and 11221 to validation set. Ten variables were significantly associated with COPD independently in development set after a stepwise selection by multivariable logistic model and used to develop scoring system. The scoring system yielded good discrimination, as measured by AUC of 0.7737, and in the validation set, the AUC was 0.7711. When applying a cutoff point of ≥16, the sensitivity in development set was 0.69 (0.67 - 0.71); specificity 0.72 (0.71 - 0.73), PPV 0.25 (0.24 - 0.26) and NPV 0.94 (0.94 - 0.95).
CONCLUSION: We developed and validated a comprehensive screening questionnaire, COPD-CPHS, with good discrimination. The score system still needs to be validated by large cohort in the future.
UNLABELLED: Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2022.2042504 .