Медицинская библиотека · Science (New York, N.Y.) · 2022
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure.
Reynolds Catherine J, Pade Corinna, Gibbons Joseph M, Otter Ashley D, Lin Kai-Min, Muñoz Sandoval Diana, Pieper Franziska P, Butler David K, Liu Siyi, Joy George, Forooghi Nasim, Treibel Thomas A, Manisty Charlotte, Moon James C, COVIDsortium Investigators§, COVIDsortium Immune Correlates Network§, Semper Amanda, Brooks Tim, McKnight Áine, Altmann Daniel M, Boyton Rosemary J, Abbass Hakam, Abiodun Aderonke, Alfarih Mashael, Alldis Zoe, Altmann Daniel M, Amin Oliver E, Andiapen Mervyn, Artico Jessica, Augusto João B, Baca Georgina L, Bailey Sasha N L, Bhuva Anish N, Boulter Alex, Bowles Ruth, Boyton Rosemary J, Bracken Olivia V, O'Brien Ben, Brooks Tim, Bullock Natalie, Butler David K, Captur Gabriella, Carr Olivia, Champion Nicola, Chan Carmen, Chandran Aneesh, Coleman Tom, Couto de Sousa Jorge, Couto-Parada Xose, Cross Eleanor, Cutino-Moguel Teresa, D'Arcangelo Silvia, Davies Rhodri H, Douglas Brooke, Di Genova Cecilia, Dieobi-Anene Keenan, Diniz Mariana O, Ellis Anaya, Feehan Karen, Finlay Malcolm, Fontana Marianna, Forooghi Nasim, Francis Sasha, Gibbons Joseph M, Gillespie David, Gilroy Derek, Hamblin Matt, Harker Gabrielle, Hemingway Georgia, Hewson Jacqueline, Heywood Wendy, Hickling Lauren M, Hicks Bethany, Hingorani Aroon D, Howes Lee, Itua Ivie, Jardim Victor, Lee Wing-Yiu Jason, Jensen Melaniepetra, Jones Jessica, Jones Meleri, Joy George, Kapil Vikas, Kelly Caoimhe, Kurdi Hibba, Lambourne Jonathan, Lin Kai-Min, Liu Siyi, Lloyd Aaron, Louth Sarah, Maini Mala K, Mandadapu Vineela, Manisty Charlotte, McKnight Áine, Menacho Katia, Mfuko Celina, Mills Kevin, Millward Sebastian, Mitchelmore Oliver, Moon Christopher, Moon James, Muñoz Sandoval Diana, Murray Sam M, Noursadeghi Mahdad, Otter Ashley, Pade Corinna, Palma Susana, Parker Ruth, Patel Kush, Pawarova Mihaela, Petersen Steffen E, Piniera Brian, Pieper Franziska P, Rannigan Lisa, Rapala Alicja, Reynolds Catherine J, Richards Amy, Robathan Matthew, Rosenheim Joshua, Rowe Cathy, Royds Matthew, Sackville West Jane, Sambile Genine, Schmidt Nathalie M, Selman Hannah, Semper Amanda, Seraphim Andreas, Simion Mihaela, Smit Angelique, Sugimoto Michelle, Swadling Leo, Taylor Stephen, Temperton Nigel, Thomas Stephen, Thornton George D, Treibel Thomas A, Tucker Art, Varghese Ann, Veerapen Jessry, Vijayakumar Mohit, Warner Tim, Welch Sophie, White Hannah, Wodehouse Theresa, Wynne Lucinda, Zahedi Dan, Chain Benjamin, Moon James C
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Аннотация
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
Для цитирования: Reynolds Catherine J, Pade Corinna, Gibbons Joseph M, Otter Ashley D, Lin Kai-Min, Muñoz Sandoval Diana, Pieper Franziska P, Butler David K, Liu Siyi, Joy George, Forooghi Nasim, Treibel Thomas A, Manisty Charlotte, Moon James C, COVIDsortium Investigators§, COVIDsortium Immune Correlates Network§, Semper Amanda, Brooks Tim, McKnight Áine, Altmann Daniel M, Boyton Rosemary J, Abbass Hakam, Abiodun Aderonke, Alfarih Mashael, Alldis Zoe, Altmann Daniel M, Amin Oliver E, Andiapen Mervyn, Artico Jessica, Augusto João B, Baca Georgina L, Bailey Sasha N L, Bhuva Anish N, Boulter Alex, Bowles Ruth, Boyton Rosemary J, Bracken Olivia V, O'Brien Ben, Brooks Tim, Bullock Natalie, Butler David K, Captur Gabriella, Carr Olivia, Champion Nicola, Chan Carmen, Chandran Aneesh, Coleman Tom, Couto de Sousa Jorge, Couto-Parada Xose, Cross Eleanor, Cutino-Moguel Teresa, D'Arcangelo Silvia, Davies Rhodri H, Douglas Brooke, Di Genova Cecilia, Dieobi-Anene Keenan, Diniz Mariana O, Ellis Anaya, Feehan Karen, Finlay Malcolm, Fontana Marianna, Forooghi Nasim, Francis Sasha, Gibbons Joseph M, Gillespie David, Gilroy Derek, Hamblin Matt, Harker Gabrielle, Hemingway Georgia, Hewson Jacqueline, Heywood Wendy, Hickling Lauren M, Hicks Bethany, Hingorani Aroon D, Howes Lee, Itua Ivie, Jardim Victor, Lee Wing-Yiu Jason, Jensen Melaniepetra, Jones Jessica, Jones Meleri, Joy George, Kapil Vikas, Kelly Caoimhe, Kurdi Hibba, Lambourne Jonathan, Lin Kai-Min, Liu Siyi, Lloyd Aaron, Louth Sarah, Maini Mala K, Mandadapu Vineela, Manisty Charlotte, McKnight Áine, Menacho Katia, Mfuko Celina, Mills Kevin, Millward Sebastian, Mitchelmore Oliver, Moon Christopher, Moon James, Muñoz Sandoval Diana, Murray Sam M, Noursadeghi Mahdad, Otter Ashley, Pade Corinna, Palma Susana, Parker Ruth, Patel Kush, Pawarova Mihaela, Petersen Steffen E, Piniera Brian, Pieper Franziska P, Rannigan Lisa, Rapala Alicja, Reynolds Catherine J, Richards Amy, Robathan Matthew, Rosenheim Joshua, Rowe Cathy, Royds Matthew, Sackville West Jane, Sambile Genine, Schmidt Nathalie M, Selman Hannah, Semper Amanda, Seraphim Andreas, Simion Mihaela, Smit Angelique, Sugimoto Michelle, Swadling Leo, Taylor Stephen, Temperton Nigel, Thomas Stephen, Thornton George D, Treibel Thomas A, Tucker Art, Varghese Ann, Veerapen Jessry, Vijayakumar Mohit, Warner Tim, Welch Sophie, White Hannah, Wodehouse Theresa, Wynne Lucinda, Zahedi Dan, Chain Benjamin, Moon James C. Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure.. Science (New York, N.Y.). 2022. DOI: 10.1126/science.abq1841.
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