[Pharmacoepidemiological analysis of outpatient-based practice of antibacterial therapy of ENT organ infections].

The objective of the present study was to estimate the effectiveness of the antibacterial therapeutic regimen based at an outpatient facility. The data for statistical analysis were collected by examining 1542 patients presenting with infections of the upper pulmonary tract and ENT organs in 10 cities of the Russian Federation. It was shown that macrolides are most commonly used to treat the above infections whereas beta-lactams are prescribed significantly less frequently. The main pharmacodynamic and pharmacokinetic features of pharmaceuticals from the group of protected penicillins are described, and the rationale is provided for their application as the medicines of choice for the treatment of infections of the upper respiratory tract at the stage of outpatient-based medical care.