Association of polymorphisms in the estrogen receptor β (ESR2) with unexplained recurrent spontaneous abortion (URSA) in Chinese population.

OBJECTIVES

To investigate the association of 1082G > A(RsaI) (rs1256049) and 1730A > G(AluI) (rs4986938) single nucleotide polymorphisms(SNPs), respectively - located on estrogen receptor β (ESR2) gene with recurrent spontaneous abortion (RSA) in Chinese population.

METHODS

The study group consisted of 196 patients with RSA and 182 fertile women as control. Two functional polymorphisms 1082G > A (a silent mutation in exon 5) and 1730A > G (3' nontranslated region of the exon 8) of ESR2 were studied by association analysis.

RESULTS

There were no significant differences between ESR2 gene polymorphisms and RSA (χ(2) =1.793, P=0.408; χ(2) =.432, P=0.489, respectively).

CONCLUSION

The present data indicate that the studied SNPs on ESR2 gene may not be associated with RSA in Chinese population.