The comparative pharmacology of benoxaprofen.

Comparative studies with nonsteroidal antiinflammatory drugs (NSAIDs) have shown benoxaprofen to be moderately active in inhibiting carrageenin-induced pleurisy in rats and cellular migration in vitro. Benoxaprofen was also moderately active in inhibiting developing adjuvant-induced arthritis; however, it exhibited a potent response in established adjuvant arthritis, and it was the only compound tested which showed marked inhibition of the directional movement of mononuclear cells. Unlike other NSAIDs, it was a weak inhibitor of prostaglandin synthetase. The data suggested that there may be mechanisms of antiinflammatory activity which do not relate to inhibition of prostaglandin synthetase.