The role of novel hormone asprosin in insulin resistance during preeclampsia.

Preeclampsia, a multisystemic syndrome of unknown etiology is characterized by hypertension and proteinuria after 20 weeks of gestation. Metabolic alterations causing insulin resistance and hyperinsulinemia are the prominent factors of preeclampsia. A novel hormone asprosin was discovered to be increased in humans with pathological conditions related to insulin resistance. This study aimed to find relationship between insulin resistance related-hormone asprosin and preeclampsia. A comparative cross-sectional study was conducted on 21 preeclamptic pregnant mothers and 21 healthy pregnant mothers. Samples were taken from mothers at the time of delivery and were processed for estimation of asprosin, insulin and glucose hormones. Data was analysed using SPSS 21. Normality of the data was checked and Independent t-test was applied. A p-value of <0.05 was considered significant. Levels of asprosin, insulin, glucose and HOMA-IR index were significantly elevated in preeclamptic pregnant mothers when compared with healthy pregnant mothers with p-values 0.000, 0.003, 0.036 and 0.002 respectively, suggesting potential role of asprosin in insulin resistance during preeclampsia.