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DOI 10.1126/scitranslmed.aau6267

Медицинская библиотека · Science translational medicine · 2019

A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment.

Verma Malvika, Vishwanath Karan, Eweje Feyisope, Roxhed Niclas, Grant Tyler, Castaneda Macy, Steiger Christoph, Mazdiyasni Hormoz, Bensel Taylor, Minahan Daniel, Soares Vance, Salama John A F, Lopes Aaron, Hess Kaitlyn, Cleveland Cody, Fulop Daniel J, Hayward Alison, Collins Joy, Tamang Siddartha M, Hua Tiffany, Ikeanyi Chinonyelum, Zeidman Gal, Mule Elizabeth, Boominathan Sooraj, Popova Ellena, Miller Jonathan B, Bellinger Andrew M, Collins David, Leibowitz Dalia, Batra Shelly, Ahuja Sandeep, Bajiya Manju, Batra Sonali, Sarin Rohit, Agarwal Upasna, Khaparde Sunil D, Gupta Neeraj K, Gupta Deepak, Bhatnagar Anuj K, Chopra Kamal K, Sharma Nandini, Khanna Ashwani, Chowdhury Jayeeta, Stoner Robert, Slocum Alexander H, Cima Michael J, Furin Jennifer, Langer Robert, Traverso Giovanni

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.

Для цитирования: Verma Malvika, Vishwanath Karan, Eweje Feyisope, Roxhed Niclas, Grant Tyler, Castaneda Macy, Steiger Christoph, Mazdiyasni Hormoz, Bensel Taylor, Minahan Daniel, Soares Vance, Salama John A F, Lopes Aaron, Hess Kaitlyn, Cleveland Cody, Fulop Daniel J, Hayward Alison, Collins Joy, Tamang Siddartha M, Hua Tiffany, Ikeanyi Chinonyelum, Zeidman Gal, Mule Elizabeth, Boominathan Sooraj, Popova Ellena, Miller Jonathan B, Bellinger Andrew M, Collins David, Leibowitz Dalia, Batra Shelly, Ahuja Sandeep, Bajiya Manju, Batra Sonali, Sarin Rohit, Agarwal Upasna, Khaparde Sunil D, Gupta Neeraj K, Gupta Deepak, Bhatnagar Anuj K, Chopra Kamal K, Sharma Nandini, Khanna Ashwani, Chowdhury Jayeeta, Stoner Robert, Slocum Alexander H, Cima Michael J, Furin Jennifer, Langer Robert, Traverso Giovanni. A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment.. Science translational medicine. 2019. DOI: 10.1126/scitranslmed.aau6267.

Предметные рубрики MeSH

AnimalsAnti-Bacterial AgentsAntitubercular AgentsDelayed-Action PreparationsDose-Response Relationship, DrugDoxycyclineDrug Delivery SystemsDrug LiberationHumansStomachSwineTuberculosis
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