[Therapeutic effects of nitroglycerin on pregnancy induced hypertension].

OBJECTIVE

To evaluate the effects and possibility of nitroglycerin on Pregnancy induced hypertension (PIH) treatment.

METHODS

In comparison with the third trimester normal pregnant women (Normal group) (n = 11), 34 moderate/severe PIH cases were divided into three groups: PIH treated only with magnesium sulfate (Mg group) (n = 11); PIH treated only with nitroglycerin (Ng group) (n = 11); and PIH treated with Mg + Ng (Combination group) (n = 12). The endothelial nitric oxide synthase (eNOS) in placenta was investigated immunohistochemically and quantitatively. Data such as platelet aggregation (PAg), umbilical artery of S/D ratio and resistance index (RI) with color Doppler and the effect of decrement of blood pressure on PHI groups were evaluated.

RESULTS

In comparision with Normal group, (1) the quantity of eNOS of PIH cases was significantly lower (P < 0.01). (2) umbilical artery S/D ratio and RI in Ng group were significantly lower after introvascular drip of Ng (P < 0.05). (3) Pag in Ng group and Combination group decreased significantly after treatment (P < 0.01), but no difference in Mg group. (4) the decrement of blood pressure on PIH groups, compared with Mg group, was significant in Ng group and Combination groups (P < 0.05).

CONCLUSIONS

Ng can reduce blood pressure, fetal-placenta circulation resistance, and inhibit PAg. It probably play a role on intrauterine growth retardation (IUGR) caused by PIH.