Iridal-type triterpenoids and stilbenes with anti-inflammatory activities from the rhizomes of Iris domestica.

Five previously undescribed iridal-type triterpenoids (belamcaniridals A-C and polycycloiridals U-V), three undescribed stilbenes (belamcanenes C, D, F), and thirteen known compounds were isolated from the rhizomes of Iris domestica. The chemical structures of the unknown compounds were established by interpreting extensive spectroscopic data, including HR-ESIMS, NMR and ECD. The previously undescribed iridal-type triterpenoids isolated had a certain degree of novelty in structure. Stilbenes (mixture 6, 8) exhibited anti-inflammatory activities with inhibition rates of 65.31 ± 0.16 % and 64.53 ± 0.09 %, respectively, against the NF-κB signaling pathway at a concentration of 10 μM. Compounds 18 and 20 exhibited antiproliferative activities against the K562 human leukemia cell line with IC50 values of 15.54 ± 1.52 μM (18) and 4.20 ± 0.70 μM (20), respectively.