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DOI 10.1111/aji.12708

Медицинская библиотека · American journal of reproductive immunology (New York, N.Y. : 1989) · 2017

Abnormal ratio of CD57+ cells to CD56+ cells in women with recurrent implantation failure.

Jiang Ruiwei, Yan Guijun, Xing Jun, Wang Zhilong, Liu Yong, Wu Hongyan, Fan Xiangshan, Zhou Jianjun, Ding Lijun, Sun Haixiang

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Аннотация

PROBLEM: To define a more precise parameter for a better understanding of natural killer (NK) cells and its relation with regulatory T cells (Tregs) in women with recurrent implantation failure (RIF).

METHOD OF STUDY: The percentages of CD56+ cells, CD57+ cells and Foxp3+ cells in the endometrium and blood from 23 normal controls and 32 women with RIF were measured by immunocytochemistry and flow cytometry.

RESULTS

Women with RIF had significantly increased ratio of CD57+ cells to CD56+ cells in both the endometrium (P<.01) and blood (P<.05), and decreased percentage of Foxp3+ cells in the endometrium (P<.05). There was a significant negative correlation between CD57+ cells to CD56+ cells ratio and the percentage of Foxp3+ cells in the blood of RIF patients (P<.05).

CONCLUSION

Our study provides a novel assessment parameter, CD57+ cells to CD56+ cells ratio, to evaluate NK cells and its relation with Tregs in RIF patients.

Для цитирования: Jiang Ruiwei, Yan Guijun, Xing Jun, Wang Zhilong, Liu Yong, Wu Hongyan, Fan Xiangshan, Zhou Jianjun, Ding Lijun, Sun Haixiang. Abnormal ratio of CD57+ cells to CD56+ cells in women with recurrent implantation failure.. American journal of reproductive immunology (New York, N.Y. : 1989). 2017. DOI: 10.1111/aji.12708.

Предметные рубрики MeSH

Abortion, HabitualAdultCD56 AntigenCD57 AntigensCell SeparationEmbryo ImplantationEndometriumFemaleFlow CytometryForkhead Transcription FactorsHumansImmunohistochemistryKiller Cells, NaturalPregnancyT-Lymphocytes, Regulatory
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