Lipoxin A4 (LXA4) as a potential first trimester biochemical marker of intrauterine growth disorders.

OBJECTIVE

To evaluate first trimester maternal serum levels of lipoxin A4 (LXA4) in prediction of intrauterine fetal growth.

METHODS

Study group of 185 patients in singleton pregnancy was divided into three subgroups according to neonatal birthweight: ≤10th percentile (SGA), 11-89th percentile (AGA) and ≥90 percentile (LGA).

RESULTS

We observed decreased values of LXA4 concentrations, both in SGA- and LGA groups, when compared to AGA (68.91 ± 33.72 and 68.30 ± 23.49 versus 102.13 ± 121.90, respectively).

CONCLUSIONS

Lipoxin A4 may become an biochemical marker in the prediction of intrauterine fetal growth disturbances; however, more studies need to be undertaken to investigate LXA4's role in pregnancy.