Cornea · 2022
Acute Corneal Epithelial Rejection of LR-CLAL After SARS-CoV-2 Vaccination.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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de la Presa Martin, Govil Amit, Chamberlain Winston D, Holland Edward J
Аннотация
PURPOSE: The purpose of this study was to report a case of acute corneal epithelial rejection of living-related conjunctival limbal allograft (LR-CLAL) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
OBSERVATIONS: A 27-year-old woman developed acute epithelial rejection of LR-CLAL 2 weeks after receiving the SARS-CoV-2 vaccine. She received the LR-CLAL transplant 4 years and 7 months previously and had a stable clinical course with no history of rejection. She had an ABO blood group and human leukocyte antigen compatible donor, no systemic comorbidities, and no rejection risk factors.
CONCLUSIONS: The novel SARS-CoV-2 vaccine upregulates the immune system to produce an adaptive immune response. The SARS-CoV-2 vaccine may potentially be associated with increased risk of rejection in those with ocular surface transplants.
OBSERVATIONS: A 27-year-old woman developed acute epithelial rejection of LR-CLAL 2 weeks after receiving the SARS-CoV-2 vaccine. She received the LR-CLAL transplant 4 years and 7 months previously and had a stable clinical course with no history of rejection. She had an ABO blood group and human leukocyte antigen compatible donor, no systemic comorbidities, and no rejection risk factors.
CONCLUSIONS: The novel SARS-CoV-2 vaccine upregulates the immune system to produce an adaptive immune response. The SARS-CoV-2 vaccine may potentially be associated with increased risk of rejection in those with ocular surface transplants.
Предметные рубрики MeSH
2019-nCoV Vaccine mRNA-1273Acute DiseaseAdministration, OphthalmicAdministration, OralAdultAllograftsCOVID-19ConjunctivaEpithelium, CornealFemaleGlucocorticoidsGraft RejectionHumansImmunosuppressive AgentsLimbus CorneaeLiving DonorsMycophenolic AcidOphthalmic SolutionsSlit Lamp MicroscopyStem Cell TransplantationTacrolimusVaccinationVisual Acuity