[Creutzfeldt-Jakob disease and Gerstmann-Sträussler syndrome with reference to their differential diagnosis].

Differential diagnosis has quite often proved to be difficult between CREUTZFELDT-JAKOB disease (CJD) and GERSTMANN-STRAUSSLER syndrome. Clinical and morphological aspects as well as the pathological course and differential diagnosis of CJD and Gerstmann-Strüssler syndrome are discussed in some detail. Slow influence can be morphologically diagnosed with reference to the overall pattern of individual alterations with inclusion of scrapie-associated fibrils. This morphological diagnosis can be verified by experimental inoculation to susceptible animals.