Drug delivery · 2014
Enhanced hepatoprotective activity of andrographolide complexed with a biomaterial.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Thingale Amol D, Shaikh Karimunnisa S, Channekar Prajakta R, Galgatte Upendra C, Chaudhari Praveen D, Bothiraja Chellampillai
Аннотация
CONTEXT: Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor therapeutic application.
OBJECTIVE: The present study investigates the complexation of AGP with HA to increase its solubility and hepatoprotective efficacy.
MATERIALS AND METHODS: Complexes prepared by solvent evaporation in various weight ratios were characterized using differential scanning calorimetry, Fourier Transform InfraRed spectroscopy, X-ray diffraction, and scanning electron microscopy.
RESULTS AND DISCUSSION: The complexed AGP demonstrated improved solubility, dissolution, and permeation across rat intestine. It also displayed better hepatoprotection against carbontetrachloride-induced liver toxicity than the free drug in rats.
CONCLUSION: Complexation with HA is a valuable technique to improve solubility and bioavailability of pharmaceuticals.
OBJECTIVE: The present study investigates the complexation of AGP with HA to increase its solubility and hepatoprotective efficacy.
MATERIALS AND METHODS: Complexes prepared by solvent evaporation in various weight ratios were characterized using differential scanning calorimetry, Fourier Transform InfraRed spectroscopy, X-ray diffraction, and scanning electron microscopy.
RESULTS AND DISCUSSION: The complexed AGP demonstrated improved solubility, dissolution, and permeation across rat intestine. It also displayed better hepatoprotection against carbontetrachloride-induced liver toxicity than the free drug in rats.
CONCLUSION: Complexation with HA is a valuable technique to improve solubility and bioavailability of pharmaceuticals.