[Disorders of protein metabolism in neonatal hyperbilirubinemia and their correction by extracorporeal detoxification].

A close relationship was established between the gravity of bilirubin intoxication, dysproteinemia and hyperpeptidemia in neonates. It is shown that accumulation of peptides belonging to the medium molecule group and associated pathophysiological manifestations may account for a graver course and less favourable prognosis of hemolytic disease of the newborn as compared to conjugation hyperbilirubinemia. It is suggested that the measures aimed at bilirubin removal by the control of the medium molecule effects should be supplemented. The results of hemosorption (51 sessions in 42 children) and substitution transfusion (27 operations in 24 children) were subjected to clinical and laboratory comparisons. In addition to bilirubin removal from the body, hemoperfusion permits the correction of protein metabolism abnormalities occurring in hemolytic disease.