Effect of Buddleja cordata Leaf Extract on Diabetic Nephropathy in Rats.

One of complications of diabetes mellitus is diabetic nephropathy. In Mexico, in traditional medicine, Buddleja cordata Humb. Bonpl. & Kunth, ("tepozán blanco") is a shrub plant used for the treatment of rheumatic diseases, postpartum bath, stomachache, skin burns, diarrhea in children, sores, and cancer.

Objectives

We examined the effect of methanol extract of leaves of B. cordata on the expression of pro-inflammatory cytokines and its antioxidant effects in diabetic nephropathy.

Methods

We used the streptozotocin-induced diabetes mellitus model in rats; these were treated with methanol extract from leaves of B. cordata at 50 and 100 mg/kg (orally) for 4 weeks. Kidney weight/total body weight ratio and proteins/DNA, proteinuria and creatinine clearance, Western blot of nuclear factor κΒ (NFkB) p65 (cytoplasm and nucleus), peroxisome proliferator activated receptor gamma (PPARγ), and activities of glutathione peroxidase, superoxide dismutase, and catalase were determined.