Experimental transmission of human subacute spongiform encephalopathy to small rodents. III. Further transmission from three patients and distribution patterns of lesions in mice.

Further experimental transmission of Creutzfeldt-Jakob disease (CJD) from three patients to mice and rats was carried out successfully. The clinical signs and pathologic features of spongiform encephalopathy transmitted to animals were much the same as in previous experiments, except that distribution of the lesions in the mice differed with each inoculated material taken from the patients. These observations suggest that multiplicity of CJD agents, as in the case of scrapie agents.