Adiponectin 1 receptor is increased but not adiponectin levels in the tumour microenvironment of postmenopausal women with breast cancer.

BACKGROUND

To analyze the ADIPOQ and ADIPOR1 levels in breast tumour tissue and adjacent adipose tissue of postmenopausal women with this cancer. We hypothesized that the tumour microenvironment (TME) of the breast had lower levels of ADIPOQ and ADIPOR1 in postmenopausal women with obesity than in those with a normal BMI.

METHODS AND

RESULTS

Twenty women with normal body mass index (BMI) and 20 with obesity, all of them postmenopausal and with breast cancer (BC) were included. We obtained during surgery fresh breast tumour tissue and a fragment of breast adipose tissue adjacent to the tumour and analyzed the levels of adiponectin (ADIPOQ) and its receptor ADIPOR1 by Western blot. Statistical power of the study was > 80% with a p < 0.05ADIPOR1 protein levels were higher in breast tumour tissue versus breast adipose tissue adjacent to the tumour in postmenopausal women with normal BMI and postmenopausal women with obesity (p = 0.0012 and p = 0.0001, respectively). Moreover, we observed higher ADIPOR1 levels only in breast adipose tissue adjacent to the tumour in postmenopausal women with obesity and tumour size > 2.0 cm and clinical stage II/III (p = 0.019 and p = 0.025, respectively) versus postmenopausal women with a normal BMI. We did not observe differences in ADIPOQ.

CONCLUSIONS

ADIPOR1 levels were higher in breast tumour tissue compared to breast adipose tissue adjacent to the tumour in both postmenopausal women with normal BMI or with obesity. Besides, ADIPOR1 levels were higher in breast adipose tissue adjacent to the tumour of postmenopausal women and obesity, with a more aggressive breast tumour.