Nerve growth factors from snake venoms: chemical properties, mode of action and biological significance.

An overview of nerve growth factors (NGF) and their receptor system is presented. This general introduction deals with mouse and human NGF, since most of the fundamental knowledge is based on these mammalian proteins. Great emphasis is laid on the nonneuronal NGF effects which are well discussed for their possible toxinological function. The snake venom NGFs were reviewed with respect to their purification, classification and properties. From the date of their discovery about 40 years ago, researchers have been interested in the possible function of mouse salivary and snake venom NGFs. The physiological relevance of snake venom NGF is therefore widely discussed on the base of experimental facts and hypothetical considerations.