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Войти в исследования Oral diseases · 2026
Dietary Profile, Soluble Receptor for Advanced Glycation End Products (sRAGE) and Interleukin-6 in Individuals With Obesity and Periodontitis.
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Ramírez José Carlos López, Vega-Cárdenas Mariela, Vargas-Morales Juan Manuel, Zumarán Alan Martínez, Rider Ricardo Martínez, Flores-Sánchez Jorge, Luevano-Contreras Claudia, Patiño-Marín Nuria, Aradillas-García Celia
Аннотация
AIM: To evaluate the dietary profile and concentrations of soluble receptors for advanced glycation end products (sRAGE) and interleukin-6 (IL-6) in overweight or obese individuals with periodontitis.
METHODS: Ninety-eight adults aged 18-59 years were classified into four groups: Normal weight no periodontitis (n = 27), normal weight with periodontitis (n = 21), overweight/obesity no periodontitis (n = 26) and overweight/obesity with periodontitis (n = 24). Dietary, clinical, anthropometric, and biochemical data were collected. sRAGE and IL-6 concentrations were measured in serum and gingival crevicular fluid (GCF) using ELISA.
RESULTS: Overweight/obesity and periodontitis group showed reduced serum sRAGE concentrations 979 [770-1193] pg/mL and elevated GCF IL-6 levels 11.4 [10.0-13.3] pg/mL (p < 0.05). Serum sRAGE and GCF IL-6 showed significant correlations with periodontal parameters, including probing pocket depth, clinical attachment loss, and number of diseased teeth (r = 0.40; p < 0.001). Despite higher total nutrient intake, overweight/obesity with periodontitis group had the highest energy intake and the highest prevalence of inadequate intake for protein (79%), calcium (92%), vitamin B5 (83%), and cholesterol (83%).
CONCLUSIONS: Obesity and periodontitis were associated with lower serum sRAGE, higher GCF IL-6, and more frequent dietary inadequacies, suggesting a potential link between nutritional status, inflammatory biomarkers, and periodontal health.
METHODS: Ninety-eight adults aged 18-59 years were classified into four groups: Normal weight no periodontitis (n = 27), normal weight with periodontitis (n = 21), overweight/obesity no periodontitis (n = 26) and overweight/obesity with periodontitis (n = 24). Dietary, clinical, anthropometric, and biochemical data were collected. sRAGE and IL-6 concentrations were measured in serum and gingival crevicular fluid (GCF) using ELISA.
RESULTS: Overweight/obesity and periodontitis group showed reduced serum sRAGE concentrations 979 [770-1193] pg/mL and elevated GCF IL-6 levels 11.4 [10.0-13.3] pg/mL (p < 0.05). Serum sRAGE and GCF IL-6 showed significant correlations with periodontal parameters, including probing pocket depth, clinical attachment loss, and number of diseased teeth (r = 0.40; p < 0.001). Despite higher total nutrient intake, overweight/obesity with periodontitis group had the highest energy intake and the highest prevalence of inadequate intake for protein (79%), calcium (92%), vitamin B5 (83%), and cholesterol (83%).
CONCLUSIONS: Obesity and periodontitis were associated with lower serum sRAGE, higher GCF IL-6, and more frequent dietary inadequacies, suggesting a potential link between nutritional status, inflammatory biomarkers, and periodontal health.