Movement disorders clinical practice · 2021
β-Blocker-Induced Tremor.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Al-Shorafat Duha M, Bhowmick Suvorit, Espay Alberto J, Fasano Alfonso
Аннотация
BACKGROUND: Although the β-blocker propranolol is considered one of the most effective tremor treatments and other β-blockers are often prescribed to patients with tremor, those with partial β-agonist activity on β-adrenoreceptors can theoretically induce or exacerbate tremor. Here we report 2 patients with tremor induced or worsened by such β-blockers.
CASES: Case 1 is a 38-year-old man with worsening of tremor in both upper extremities after the introduction of pindolol as an adjunct treatment for severe depression. The tremor improved 1 month after discontinuing this medication. Case 2 is a 77-year-old woman with new bilateral hand tremor after receiving labetalol for the management of hypertension during a hospital admission. Tremor markedly attenuated after eliminating labetalol.
CONCLUSION: β-Blockers with partial agonist activity can induce or exacerbate tremor.
CASES: Case 1 is a 38-year-old man with worsening of tremor in both upper extremities after the introduction of pindolol as an adjunct treatment for severe depression. The tremor improved 1 month after discontinuing this medication. Case 2 is a 77-year-old woman with new bilateral hand tremor after receiving labetalol for the management of hypertension during a hospital admission. Tremor markedly attenuated after eliminating labetalol.
CONCLUSION: β-Blockers with partial agonist activity can induce or exacerbate tremor.