Медицинская библиотека · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2005

[Expression and significance of mRNA for MIP-1alpha in cerebral tissue of newborn rat with hypoxic-ischemic brain damage].

Zhang Tao, Li Ping

Аннотация на английскомСтатьяПеревод в очереди

Аннотация

OBJECTIVE

To observe the expression of mRNA for the MIP-1alpha in cerebral tissue after hypoxic-ischemic brain damage (HIBD) in newborn rat.

METHODS

The dynamic changes of expression of MIP-1alpha mRNA were studied using 7 d-old SD rat hypoxic-ischemic brain damage model and quantitative, real-time, fluorogenic PCR (TaqMan) assay.

RESULTS

Peaking transcription was shown at 6 hours after HIBD when MIP-1alpha mRNA level in the HI cerebral hemisphere was almost 10 times compared with that of control group. The mRNA level of 12 and 24 hours after HIBD was also greater than that of control group.

CONCLUSION

This appearance suggests that, as an inflammatory mediator, the MIP-1alpha transcription after HIBD may play important roles in the evolvement of brain damage.

Для цитирования: Zhang Tao, Li Ping. [Expression and significance of mRNA for MIP-1alpha in cerebral tissue of newborn rat with hypoxic-ischemic brain damage].. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2005.

Предметные рубрики MeSH

Animals Animals, Newborn Chemokine CCL3 Chemokine CCL4 Female Hypoxia-Ischemia, Brain Macrophage Inflammatory Proteins Male RNA, Messenger Rats Rats, Sprague-Dawley

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