Contribution of the "Stefan S. Nicolau" Institute of Virology to the electron microscopic study of viruses.

The review reflects the concerns of researchers of the "Stefan S. Nicolau" Institute of Virology who used electron microscopy techniques with a view to visualizing morphological features of virus structure (influenza, adeno, hepatitis, herpes, cytomegalic, Aujeszky, rabies viruses, etc.) and different aspects of the virus - host cell relationships (Sendai virus/Hep2 cells, influenza and adenovirus/mouse lung, subacute sclerosing panencephalitis/human brain or cell cultures, Coxsackie and foot-and-mouth disease virus/myofibrils, Rubarth hepatitis virus/chick embryo liver cells, a.o.). Morphological aspects of normal or tumoral cells and the influence of chemical agents (actinomycin D, EDTA), viruses, bacteria or parasites have also been studied. Mention is made of several original techniques used to obtain electron microscopy preparations.