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DOI 10.1038/s43856-024-00474-2

Медицинская библиотека · Communications medicine · 2024

Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors.

Kjerulff Bertram, Dowsett Joseph, Jacobsen Rikke Louise, Gladov Josephine, Larsen Margit Hørup, Lundgaard Agnete Troen, Banasik Karina, Westergaard David, Mikkelsen Susan, Dinh Khoa Manh, Hindhede Lotte, Kaspersen Kathrine Agergård, Schwinn Michael, Juul Anders, Poulsen Betina, Lindegaard Birgitte, Pedersen Carsten Bøcker, Sabel Clive Eric, Bundgaard Henning, Nielsen Henriette Svarre, Møller Janne Amstrup, Boldsen Jens Kjærgaard, Burgdorf Kristoffer Sølvsten, Kessing Lars Vedel, Handgaard Linda Jenny, Thørner Lise Wegner, Didriksen Maria, Nyegaard Mette, Grarup Niels, Ødum Niels, Johansson Pär I, Jennum Poul, Frikke-Schmidt Ruth, Berger Sanne Schou, Brunak Søren, Jacobsen Søren, Hansen Thomas Folkmann, Lundquist Tine Kirkeskov, Hansen Torben, Sørensen Torben Lykke, Sigsgaard Torben, Nielsen Kaspar René, Bruun Mie Topholm, Hjalgrim Henrik, Ullum Henrik, Rostgaard Klaus, Sørensen Erik, Pedersen Ole Birger, Ostrowski Sisse Rye, Erikstrup Christian

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Аннотация

BACKGROUND

The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences.

METHODS

A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking.

RESULTS

Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers.

CONCLUSION

This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.

Для цитирования: Kjerulff Bertram, Dowsett Joseph, Jacobsen Rikke Louise, Gladov Josephine, Larsen Margit Hørup, Lundgaard Agnete Troen, Banasik Karina, Westergaard David, Mikkelsen Susan, Dinh Khoa Manh, Hindhede Lotte, Kaspersen Kathrine Agergård, Schwinn Michael, Juul Anders, Poulsen Betina, Lindegaard Birgitte, Pedersen Carsten Bøcker, Sabel Clive Eric, Bundgaard Henning, Nielsen Henriette Svarre, Møller Janne Amstrup, Boldsen Jens Kjærgaard, Burgdorf Kristoffer Sølvsten, Kessing Lars Vedel, Handgaard Linda Jenny, Thørner Lise Wegner, Didriksen Maria, Nyegaard Mette, Grarup Niels, Ødum Niels, Johansson Pär I, Jennum Poul, Frikke-Schmidt Ruth, Berger Sanne Schou, Brunak Søren, Jacobsen Søren, Hansen Thomas Folkmann, Lundquist Tine Kirkeskov, Hansen Torben, Sørensen Torben Lykke, Sigsgaard Torben, Nielsen Kaspar René, Bruun Mie Topholm, Hjalgrim Henrik, Ullum Henrik, Rostgaard Klaus, Sørensen Erik, Pedersen Ole Birger, Ostrowski Sisse Rye, Erikstrup Christian. Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors.. Communications medicine. 2024. DOI: 10.1038/s43856-024-00474-2.
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