International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2008
Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Jou Hei-Jen, Wu Shiao-Chi, Chang Fang-Wei, Ling Pei-Ying, Chu Kung Shen, Wu Wen-Huey
Аннотация
OBJECTIVE: To evaluate the effect of soy isoflavones on menopausal symptoms in women who do and who do not produce equol, a daidzein metabolite.
METHOD: A randomized, double-blind, placebo-controlled clinical trial was conducted over 6 months with 96 healthy menopausal women. After taking take 135 mg of isoflavones daily for 1 week, the women in the study group were assigned to the equol-producing (EP) or the non-EP group according to the presence or absence of equol in their urine. Menopausal symptoms were evaluated using a modified Kupperman Index.
RESULT: Compared with the placebo group, the scores for hot flashes and excessive sweating were significantly reduced after 3 months, and the scores for weakness, palpitations, limb paresthesia, and total symptoms after 6 months, in the EP group only.
CONCLUSIONS: Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.
METHOD: A randomized, double-blind, placebo-controlled clinical trial was conducted over 6 months with 96 healthy menopausal women. After taking take 135 mg of isoflavones daily for 1 week, the women in the study group were assigned to the equol-producing (EP) or the non-EP group according to the presence or absence of equol in their urine. Menopausal symptoms were evaluated using a modified Kupperman Index.
RESULT: Compared with the placebo group, the scores for hot flashes and excessive sweating were significantly reduced after 3 months, and the scores for weakness, palpitations, limb paresthesia, and total symptoms after 6 months, in the EP group only.
CONCLUSIONS: Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.