Fertility and sterility · 2011
Frozen-thawed blastocyst transfer reduces ectopic pregnancy risk: an analysis of single embryo transfer cycles in Japan.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Ishihara Osamu, Kuwahara Akira, Saitoh Hidekazu
Аннотация
OBJECTIVE: To evaluate the effect of frozen-thawed blastocyst transfer on ectopic pregnancy (EP) rate.
DESIGN: Retrospective analysis.
SETTING: Japanese registry of assisted reproductive medicine.
PATIENT(S): Women who were registered during 2008.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Rates of live birth, EP, and spontaneous abortion in single blastocyst and cleavage-stage ET cycles in both fresh and frozen-thawed were determined.
RESULT(S): In the frozen-thawed single blastocyst transfer cycles, 84 EPs of 10,312 clinical pregnancies (0.81%) were reported. There were 25 EPs of 1,361 clinical pregnancies (1.8%) in fresh IVF single blastocyst transfer cycles and 19 of 1,352 (1.4%) in fresh intracytoplasmic sperm injection single blastocyst transfer cycles. The rate of EPs after frozen-thawed single blastocyst transfers varied between 0.56% and 0.97% after stratification by age group.
CONCLUSION(S): Frozen-thawed blastocyst transfers have reduced EP rates significantly compared with fresh blastocyst transfers.
DESIGN: Retrospective analysis.
SETTING: Japanese registry of assisted reproductive medicine.
PATIENT(S): Women who were registered during 2008.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Rates of live birth, EP, and spontaneous abortion in single blastocyst and cleavage-stage ET cycles in both fresh and frozen-thawed were determined.
RESULT(S): In the frozen-thawed single blastocyst transfer cycles, 84 EPs of 10,312 clinical pregnancies (0.81%) were reported. There were 25 EPs of 1,361 clinical pregnancies (1.8%) in fresh IVF single blastocyst transfer cycles and 19 of 1,352 (1.4%) in fresh intracytoplasmic sperm injection single blastocyst transfer cycles. The rate of EPs after frozen-thawed single blastocyst transfers varied between 0.56% and 0.97% after stratification by age group.
CONCLUSION(S): Frozen-thawed blastocyst transfers have reduced EP rates significantly compared with fresh blastocyst transfers.