Ocular immunology and inflammation · 2026
Presumed Bilateral Retinitis Associated with JC Virus in a Patient with HIV AIDS.
СтатьяНазвание и аннотация: Перевод в очереди
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Tetik Aylin, Goupillou Paul, Toutée Adélaïde, Lemée Ludovic, Cappy Pierre, Vandendriessche Anne, Muraine Marc, Gueudry Julie
Аннотация
PURPOSE: To report the clinical characteristics of JC virus (JCV) retinitis.
METHODS: A retrospective case report.
RESULTS: A 29-year-old male patient, diagnosed with HIV at AIDS stage, had brain lesions compatible with progressive multifocal leukoencephalopathy. Fundus examination showed areas of retinal atrophy and changes in the pigment epithelium. A similar worsening of the retinal and brain lesions was observed, despite several treatments. The vitreous sample analyzed using Next Generation Sequencing analysis was positive for JCV. No other pathogens were identified. The retinal lesions finally stabilized, concomitantly with the brain lesions, due to immune restoration.
CONCLUSION: We report here a case of presumed JCV-related atypical retinitis associated with a progressive multifocal leukoencephalopathy in a patient with AIDS.
METHODS: A retrospective case report.
RESULTS: A 29-year-old male patient, diagnosed with HIV at AIDS stage, had brain lesions compatible with progressive multifocal leukoencephalopathy. Fundus examination showed areas of retinal atrophy and changes in the pigment epithelium. A similar worsening of the retinal and brain lesions was observed, despite several treatments. The vitreous sample analyzed using Next Generation Sequencing analysis was positive for JCV. No other pathogens were identified. The retinal lesions finally stabilized, concomitantly with the brain lesions, due to immune restoration.
CONCLUSION: We report here a case of presumed JCV-related atypical retinitis associated with a progressive multifocal leukoencephalopathy in a patient with AIDS.