Infectious disease reports · 2026
Progressive Multifocal Leukoencephalopathy in AIDS: The Diagnostic Role of PET Imaging.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Donini Virginia, Paggi Riccardo, Farese Alberto, Malcontenti Costanza, Tagliaferri Enrico, Caroselli Claudio, Sani Spartaco, Matteini Maria, Bartoloni Alessandro, Zammarchi Lorenzo
Аннотация
INTRODUCTION: The majority of progressive multifocal leukoencephalopathy (PML) cases is still represented by patients affected by acquired immunodeficiency syndrome (AIDS). Diagnosis of PML relies on histopathological findings or by the combination of clinical signs, radiological evidence, and molecular positivity of the JC virus in cerebrospinal fluid. However, AIDS status predisposes to various diseases involving the brain, testing the diagnostic ability of the clinician.
CASE DESCRIPTION: We describe a PML case in a patient with AIDS, in whom lumbar puncture was initially impossible for severe thrombocytopenia and magnetic resonance showed an hyperintense lesion and was unable to distinguish between PML and lymphoma. In this case, [18F]-fluorodeoxyglucose (FDG)-PET imaging showing a hypometabolism of the lesion helped to initially orient toward PML, as diagnosis was later confirmed by lumbar puncture. We collected 21 cases in the literature in which [18F]-FDG-PET was helpful in cases of PML.
DISCUSSION AND CONCLUSIONS: PET imaging is not considered a standard diagnostic tool for PML. However, in selected cases, it may provide valuable information to direct the diagnosis towards PML.
CASE DESCRIPTION: We describe a PML case in a patient with AIDS, in whom lumbar puncture was initially impossible for severe thrombocytopenia and magnetic resonance showed an hyperintense lesion and was unable to distinguish between PML and lymphoma. In this case, [18F]-fluorodeoxyglucose (FDG)-PET imaging showing a hypometabolism of the lesion helped to initially orient toward PML, as diagnosis was later confirmed by lumbar puncture. We collected 21 cases in the literature in which [18F]-FDG-PET was helpful in cases of PML.
DISCUSSION AND CONCLUSIONS: PET imaging is not considered a standard diagnostic tool for PML. However, in selected cases, it may provide valuable information to direct the diagnosis towards PML.