MedElevator
Войти в исследования Revista de neurologia · 1999
[Antiplatelet therapy of secondary stroke prevention after ESPS-2 and CAPRIE].
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Alvarez-Sabín J, Montaner-Villalonga J
Аннотация
INTRODUCTION: Antiplatelet therapy is effective for secondary prevention of atherothrombotic stroke. Aspirin, the more frequently used antiplatelet drug, prevents 13 to 17% of ischemic events after stroke. New and more effective antiplatelet therapies are needed.
DEVELOPMENT: Two large secondary stroke prevention trials have been recently published (CAPRIE and ESPS-2), including more than 25,000 patients. As well TACIP trial designed to assess the efficacy of triflusal, is close to end. The combination of ticlopidine and Aspirin has shown synergistic effect.
CONCLUSIONS: Clopidogrel, like ticlopidine, increase 9% the relative risk reduction of stroke over Aspirin. Clopidogrel has a better safety profile than ticlopidine. Dipyridamole is an effective antiplatelet drug, but in combination with low doses of Aspirin is more effective. The possible efficacy of clopidogrel-Aspirin combination should be evaluated.
DEVELOPMENT: Two large secondary stroke prevention trials have been recently published (CAPRIE and ESPS-2), including more than 25,000 patients. As well TACIP trial designed to assess the efficacy of triflusal, is close to end. The combination of ticlopidine and Aspirin has shown synergistic effect.
CONCLUSIONS: Clopidogrel, like ticlopidine, increase 9% the relative risk reduction of stroke over Aspirin. Clopidogrel has a better safety profile than ticlopidine. Dipyridamole is an effective antiplatelet drug, but in combination with low doses of Aspirin is more effective. The possible efficacy of clopidogrel-Aspirin combination should be evaluated.