Frontiers in immunology · 2024
Elevation of serum neurofilament light-chain levels disclose possible occult progressive multifocal leukoencephalopathy and immune reconstitution syndrome in a patient receiving ozanimod: a case report.
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Quintanilla-Bordás Carlos, Gorriz David, Cubas-Núñez Laura, Castillo-Villalba Jéssica, Carreres-Polo Joan, Casanova Bonaventura, Pérez-Miralles Francisco Carlos
Аннотация
BACKGROUND: We report the first case of findings suggestive of progressive multifocal leukoencephalopathy and immune restitution syndrome (PML-IRIS) in a patient with multiple sclerosis receiving ozanimod preceded by an unexpected increase in the serum neurofilament light-chain (sNfL) levels.
CASE REPORT: A 57-year-old-woman treated with ozanimod for the last 8 years presented, during surveillance MRI, with findings compatible with PML-IRIS. Overt clinical symptoms were absent. sNfL levels increased 4 months earlier and peaked at presentation. Lymphocyte count reached nadir of 330/mL at 8 months earlier.
CONCLUSION: The case illustrates the utility of sNfL levels for PML surveillance in patients receiving immunosuppressors.
CASE REPORT: A 57-year-old-woman treated with ozanimod for the last 8 years presented, during surveillance MRI, with findings compatible with PML-IRIS. Overt clinical symptoms were absent. sNfL levels increased 4 months earlier and peaked at presentation. Lymphocyte count reached nadir of 330/mL at 8 months earlier.
CONCLUSION: The case illustrates the utility of sNfL levels for PML surveillance in patients receiving immunosuppressors.