Revista da Associacao Medica Brasileira (1992) · 2010
[Cytogenetic analysis of material from spontaneous abortion].
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Rolnik Daniel Lorber, Carvalho Mário Henrique Burlacchini de, Catelani Ana Lúcia Pereira Monteiro, Pinto Ana Paula Almeida Rocha, Lira Juliana Branco Gonçalves, Kusagari Neusa Kiyomi, Belline Paula, Chauffaille Maria de Lourdes
Аннотация
OBJECTIVE: To describe chromosomal abnormalities in spontaneous abortion material.
METHODS: A retrospective compilation of karyotype analysis of slides stained with Band G was carried out by optical microscopy with materials of 428 abortion products referred for study.
RESULTS: There were 145 normal results (33.9%) and 237 abnormal results (55.4%). In 46 samples there was no cell growth (10.7%). Numerical abnormalities were the most frequent, especially trisomy 16 (41 cases), triplodia (27 cases), monosomy X (26 cases), tetraploidy (13 cases) and trisomy 15 (13 cases).
CONCLUSION: Cytogenetic alterations are an important cause of pregnancy loss and their detection helps the genetic counseling to the couple. Trisomy 16 is the most often found change.
METHODS: A retrospective compilation of karyotype analysis of slides stained with Band G was carried out by optical microscopy with materials of 428 abortion products referred for study.
RESULTS: There were 145 normal results (33.9%) and 237 abnormal results (55.4%). In 46 samples there was no cell growth (10.7%). Numerical abnormalities were the most frequent, especially trisomy 16 (41 cases), triplodia (27 cases), monosomy X (26 cases), tetraploidy (13 cases) and trisomy 15 (13 cases).
CONCLUSION: Cytogenetic alterations are an important cause of pregnancy loss and their detection helps the genetic counseling to the couple. Trisomy 16 is the most often found change.