MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1038/s41467-022-28898-1

Медицинская библиотека · Nature communications · 2022

Divergent trajectories of antiviral memory after SARS-CoV-2 infection.

Tomic Adriana, Skelly Donal T, Ogbe Ane, O'Connor Daniel, Pace Matthew, Adland Emily, Alexander Frances, Ali Mohammad, Allott Kirk, Azim Ansari M, Belij-Rammerstorfer Sandra, Bibi Sagida, Blackwell Luke, Brown Anthony, Brown Helen, Cavell Breeze, Clutterbuck Elizabeth A, de Silva Thushan, Eyre David, Lumley Sheila, Flaxman Amy, Grist James, Hackstein Carl-Philipp, Halkerston Rachel, Harding Adam C, Hill Jennifer, James Tim, Jay Cecilia, Johnson Síle A, Kronsteiner Barbara, Lie Yolanda, Linder Aline, Longet Stephanie, Marinou Spyridoula, Matthews Philippa C, Mellors Jack, Petropoulos Christos, Rongkard Patpong, Sedik Cynthia, Silva-Reyes Laura, Smith Holly, Stockdale Lisa, Taylor Stephen, Thomas Stephen, Tipoe Timothy, Turtle Lance, Vieira Vinicius Adriano, Wrin Terri, OPTIC Clinical Group, PITCH Study Group, C-MORE Group, Pollard Andrew J, Lambe Teresa, Conlon Chris P, Jeffery Katie, Travis Simon, Goulder Philip, Frater John, Mentzer Alex J, Stafford Lizzie, Carroll Miles W, James William S, Klenerman Paul, Barnes Eleanor, Dold Christina, Dunachie Susanna J

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show a highly variable range of responses, some of which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B cell memory ELISpot) are stable. We use integrative analysis and a machine-learning approach (SIMON - Sequential Iterative Modeling OverNight) to explore this heterogeneity. We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory for longer term immunity associates with higher levels of neutralising antibodies against the infecting (Victoria) strain and also against variants B.1.1.7 (alpha) and B.1.351 (beta). These variable trajectories following early priming may define subsequent protection from severe disease from novel variants.

Для цитирования: Tomic Adriana, Skelly Donal T, Ogbe Ane, O'Connor Daniel, Pace Matthew, Adland Emily, Alexander Frances, Ali Mohammad, Allott Kirk, Azim Ansari M, Belij-Rammerstorfer Sandra, Bibi Sagida, Blackwell Luke, Brown Anthony, Brown Helen, Cavell Breeze, Clutterbuck Elizabeth A, de Silva Thushan, Eyre David, Lumley Sheila, Flaxman Amy, Grist James, Hackstein Carl-Philipp, Halkerston Rachel, Harding Adam C, Hill Jennifer, James Tim, Jay Cecilia, Johnson Síle A, Kronsteiner Barbara, Lie Yolanda, Linder Aline, Longet Stephanie, Marinou Spyridoula, Matthews Philippa C, Mellors Jack, Petropoulos Christos, Rongkard Patpong, Sedik Cynthia, Silva-Reyes Laura, Smith Holly, Stockdale Lisa, Taylor Stephen, Thomas Stephen, Tipoe Timothy, Turtle Lance, Vieira Vinicius Adriano, Wrin Terri, OPTIC Clinical Group, PITCH Study Group, C-MORE Group, Pollard Andrew J, Lambe Teresa, Conlon Chris P, Jeffery Katie, Travis Simon, Goulder Philip, Frater John, Mentzer Alex J, Stafford Lizzie, Carroll Miles W, James William S, Klenerman Paul, Barnes Eleanor, Dold Christina, Dunachie Susanna J. Divergent trajectories of antiviral memory after SARS-CoV-2 infection.. Nature communications. 2022. DOI: 10.1038/s41467-022-28898-1.

Предметные рубрики MeSH

Antibodies, ViralAntiviral AgentsCOVID-19HumansLongitudinal StudiesSARS-CoV-2Spike Glycoprotein, Coronavirus
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.