Therapeutic delivery · 2018
Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Mooranian Armin, Zamani Nassim, Mikov Momir, Goločorbin-Kon Svetlana, Stojanovic Goran, Arfuso Frank, Al-Salami Hani
Аннотация
AIM: Deoxycholic acid (DCA) has improved gliclazide oral absorption, while Eudragit® (ED) polymers have improved formulation stability of antidiabetic drugs. The aim of the study is to test if DCA and ED encapsulation will optimize the release and stability of the potential antidiabetic drug probucol (PB).
MATERIALS & METHODS: The PB formulations were prepared using ED polymers and DCA, and formulations were analyzed for their rheological and biological properties.
RESULTS: Rheological properties and size distribution were similar among all groups. β-cell survival and biological activities were best with NM30D microcapsules. The inflammatory profile and oxidative stress effects of microcapsules remained similar among all groups.
CONCLUSION: ED NM30D and DCA incorporation can exert positive and stabilizing effects on PB oral microcapsules.
MATERIALS & METHODS: The PB formulations were prepared using ED polymers and DCA, and formulations were analyzed for their rheological and biological properties.
RESULTS: Rheological properties and size distribution were similar among all groups. β-cell survival and biological activities were best with NM30D microcapsules. The inflammatory profile and oxidative stress effects of microcapsules remained similar among all groups.
CONCLUSION: ED NM30D and DCA incorporation can exert positive and stabilizing effects on PB oral microcapsules.
Предметные рубрики MeSH
Administration, OralAnimalsAntioxidantsBiological AvailabilityCapsulesCell LineCell SurvivalDeoxycholic AcidDrug CarriersDrug CompoundingDrug Evaluation, PreclinicalDrug LiberationHydrophobic and Hydrophilic InteractionsHypoglycemic AgentsInsulin-Secreting CellsMiceOxidative StressPolymethacrylic AcidsProbucol