Extramammary Paget's disease involving the penis, scrotum and the axilla.

A 57-year-old man with a 2-year history of extramammary Paget's disease of the penis, scrotum and the axilla attended our urology clinic. The lesion in the axilla had been noticed 14 months later than the lesion involving the penis and scrotum. We performed a resection of both local extramammary Paget's disease lesions with a 3-cm margin. Intraoperative frozen sections were also used to ascertain clear surgical margins. Neither signs of recurrence nor underlying internal malignancy has developed after 2-year follow up. From our experience, extramammary Paget's disease may occur in multiple sites. In the absence of metastatic disease and underlying internal malignancy, a wide excision is recommended in the management of multiple lesions of extramammary Paget's disease.