Successful initiation of continuous kidney replacement therapy in an extremely premature infant.

The need for kidney replacement therapy (KRT) is growing among critically ill neonates. We report an extremely preterm infant (25 1/7 weeks) who underwent successful continuous kidney replacement therapy for acute kidney injury stage 3 (AKI stage 3). This 9-day-old female infant (birth weight 690 g) was diagnosed with multisystem inflammatory syndrome in neonates (MIS-N) with multiple organ dysfunction syndrome (MODS). She had received invasive ventilatory and other indicated supportive soon after birth. On day 11 of life, because of worsening kidney parameters with dyselectrolytemia (severe hyperkalemia), continuous kidney replacement therapy (CKRT) was performed using umbilical access. This case report documents the feasibility and successful initiation of CKRT without any complications in an extremely preterm infant.